Antonino Belfiore Selected Research

Insulin-Like Growth Factor II (Somatomedin A)

1/2018	A novel functional crosstalk between DDR1 and the IGF axis and its relevance for breast cancer.
1/2017	Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells.
1/2017	PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis.
2/2016	IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway.
4/2014	Decorin differentially modulates the activity of insulin receptor isoform A ligands.
9/2012	Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma.
5/2012	Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway.
8/2011	Research resource: New and diverse substrates for the insulin receptor isoform A revealed by quantitative proteomics after stimulation with IGF-II or insulin.
3/2011	Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid.
1/2011	The insulin receptor: a new target for cancer therapy.

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Antonino Belfiore Research Topics

Disease

69	Neoplasms (Cancer) 10/2022 - 01/2002
27	Breast Neoplasms (Breast Cancer) 07/2022 - 06/2004
12	Neoplasm Metastasis (Metastasis) 10/2022 - 08/2004
9	Thyroid Neoplasms (Thyroid Cancer) 05/2020 - 01/2002
9	Prostatic Neoplasms (Prostate Cancer) 12/2017 - 03/2005
6	Inflammation (Inflammations) 10/2021 - 09/2012
6	Urinary Bladder Neoplasms (Bladder Cancer) 11/2020 - 01/2012
5	Papillary Thyroid Cancer 10/2022 - 07/2003
5	Colorectal Neoplasms (Colorectal Cancer) 03/2022 - 11/2017
5	Carcinogenesis 11/2020 - 01/2012
5	Insulin Resistance 01/2017 - 10/2009
4	Obesity 01/2022 - 08/2011
4	Hyperinsulinism (Hyperinsulinemia) 01/2022 - 10/2009
4	Type 2 Diabetes Mellitus (MODY) 08/2021 - 10/2009
4	Carcinoma (Carcinomatosis) 01/2017 - 07/2003
3	Triple Negative Breast Neoplasms 06/2022 - 11/2021
3	Lung Neoplasms (Lung Cancer) 01/2022 - 03/2009
3	Graves Ophthalmopathy 03/2021 - 01/2020
3	Hypoxia (Hypoxemia) 08/2020 - 01/2013
3	Mesothelioma 11/2019 - 08/2016
2	Hyperthyroidism 03/2021 - 01/2020
2	Graves Disease (Basedow Disease) 03/2021 - 06/2004
2	Lymphatic Metastasis 01/2019 - 08/2004
2	Glioblastoma (Glioblastoma Multiforme) 01/2019 - 01/2016
2	Leiomyosarcoma 10/2014 - 11/2002
2	Non-alcoholic Fatty Liver Disease 11/2013 - 01/2012
2	Ewing Sarcoma (Sarcoma, Ewing) 01/2013 - 09/2012
2	Sarcoma (Soft Tissue Sarcoma) 01/2013 - 01/2013
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 10/2022
1	Disease Progression 10/2022
1	Adenoma (Adenomas) 03/2022

Drug/Important Bio-Agent (IBA)

27	Insulin (Novolin)FDA Link 01/2022 - 11/2002
23	Insulin ReceptorIBA 01/2022 - 01/2002
19	Protein Isoforms (Isoforms)IBA 11/2021 - 01/2002
17	Biological ProductsIBA 01/2022 - 11/2002
17	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2018 - 01/2002
16	Insulin-Like Growth Factor I (IGF-1)IBA 02/2021 - 03/2005
16	IGF Type 1 Receptor (IGF 1 Receptor)IBA 01/2017 - 11/2002
12	Estrogen ReceptorsIBA 01/2022 - 09/2007
10	Estrogens (Estrogen)FDA Link 11/2021 - 09/2007
9	LigandsIBA 11/2020 - 08/2011
8	Biomarkers (Surrogate Marker)IBA 07/2022 - 01/2012
8	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 01/2012
7	Insulin-Like PeptidesIBA 01/2022 - 09/2007
7	Somatomedin Receptors (Somatomedin Receptor)IBA 01/2021 - 09/2007
7	ProgranulinsIBA 11/2020 - 01/2015
7	GTP-Binding Proteins (G-Protein)IBA 08/2020 - 10/2014
7	Proteins (Proteins, Gene)FDA Link 08/2020 - 06/2003
7	AndrogensIBA 12/2017 - 03/2005
6	Pharmaceutical PreparationsIBA 01/2022 - 01/2013
6	Collagen ReceptorsIBA 01/2021 - 06/2015
5	Discoidin Domain Receptor 1IBA 01/2021 - 06/2015
5	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2020 - 01/2015
4	MicroRNAs (MicroRNA)IBA 03/2022 - 01/2017
4	Androgen Receptors (Androgen Receptor)IBA 04/2014 - 03/2005
3	ErbB Receptors (EGF Receptor)IBA 01/2022 - 03/2009
3	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 01/2017
3	IntegrinsIBA 01/2019 - 01/2017
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2018 - 04/2014
3	Hypoglycemic Agents (Hypoglycemics)IBA 11/2013 - 08/2011
2	CytokinesIBA 11/2021 - 08/2020
2	Glucagon-Like Peptide 1 (GLP 1)IBA 08/2021 - 11/2013
2	Cisplatin (Platino)FDA LinkGeneric 11/2020 - 06/2016
2	Heavy MetalsIBA 05/2020 - 12/2017
2	MetalsIBA 05/2020 - 12/2017
2	Capecitabine (Xeloda)FDA Link 03/2020 - 01/2020
2	Bevacizumab (Avastin)FDA Link 01/2020 - 01/2019
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020 - 01/2020
2	EnzymesIBA 01/2019 - 07/2003
2	CollagenIBA 01/2018 - 01/2017
2	CopperIBA 12/2017 - 10/2015
2	ZincIBA 12/2017 - 01/2017
2	Trace Elements (Biometals)IBA 12/2017 - 01/2017
2	sortilinIBA 12/2017 - 01/2015
2	CateninsIBA 11/2017 - 01/2017
2	ThiazolidinedionesIBA 01/2017 - 11/2013
2	Therapeutic UsesIBA 06/2016 - 01/2013
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 02/2016 - 06/2015
2	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 04/2014 - 09/2009
2	AntibodiesIBA 09/2012 - 07/2003
2	Complementary DNA (cDNA)IBA 05/2012 - 10/2002
2	SteroidsIBA 09/2009 - 02/2009
1	cabozantinibIBA 10/2022
1	lenvatinibIBA 10/2022
1	Trastuzumab (Herceptin)FDA Link 07/2022
1	human ERBB2 proteinIBA 07/2022
1	Focal Adhesion Protein-Tyrosine KinasesIBA 06/2022
1	FilaminsIBA 06/2022
1	CarbohydratesIBA 01/2022
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2022

Therapy/Procedure

30	Therapeutics 10/2022 - 11/2002
4	Drug Therapy (Chemotherapy) 01/2022 - 01/2013
3	Glycemic Control 08/2021 - 11/2013
2	Thyroidectomy 10/2022 - 01/2019
2	Immunotherapy 01/2022 - 01/2022
2	Mediterranean Diet 10/2021 - 01/2019
2	Castration 12/2017 - 01/2015
1	Radiotherapy 10/2022
1	Lymph Node Excision (Lymph Node Dissection) 10/2022
1	Protein-Restricted Diet (Diet, Protein Restricted) 01/2022